A rare case of gastric outlet obstruction due to a large osteoclast-like giant cell tumor of the pancreatic head - A case report

Presenter: Kiarash Mashayekhi MD, MS | San Joaquin General Hospital Background: Osteoclast-like Giant Cell Tumors (OGCT) of the pancreas is extremely rare, highly aggressive tumors which are still poorly understood. To date, multiple cases have been reported characterize these as variants pancreatic giant cell and provide evidence supporting a duct epithelium origin. The current prognostic factors outcomes various treatment protocols not established however, with very few reports discussing chemotherapy regimens outcomes. Methods: This case report. Results: Here we present 45-year-old patient who presented large head mass causing gastric outlet obstruction. She otherwise had no other significant past medical history or family cancers. Diagnostic laparoscopy biopsy demonstrated intraperitoneal metastatic disease showed an undifferentiated carcinoma osteoclast-like cells. was successfully resected via Whipple procedure negative margins one fifteen lymph nodes positive for carcinoma. final pathology pT3pN1. discussed in tumor board she began adjuvant gemcitabine capecitabine, however capecitabine held due to development severe pancytopenia. Conclusion: Current literature consists several on OGCTs limited data regard different regimens. long-term benefit treatments lacking. demonstrates rare example OGCT young healthy further explores potential benefits options pancreas.